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KMID : 0389420110190040391
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Korean Journal of Stress Research
2011 Volume.19 No. 4 p.391 ~ p.396
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Stress Response in Fasted Rat
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Jung Eun-Yee
Shim In-sop
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Abstract
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We studied the stress response of the rat to different fasting periods (24 and 48 h), by measuring blood glucose, corticosterone concentration, glucocorticoid receptor (GR) in hypothalamus, plasma 5-HIAA and 5-HT. The obtained results show that fasting decreased blood glucose and increased corticosterone concentration in comparison with ad libitum fed rats. However, the GR in hypothalamus increased not in 48 h fasting but in 24 h fasting. Also, plasma 5-HIAA and 5-HT were decreased by fasting periods. It is possible that hypothalamic GR activity is sensitive to the different fasting periods and the fasting itself evokes stress response related with plasma 5-HIAA and 5-HT.
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KEYWORD
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Food deprivation, Blood glucose, Corticosterone, GR, Serotonin (5-HT)
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